---
title: "Biohub Releases ESMC, a Protein World Model Trained on 2.8B Sequences"
subtitle: "Biohub open-sources ESMC, ESMFold2, and a 6.8B-protein Atlas — beating AlphaFold 3 on antibody-antigen prediction and designing lab-validated cancer binders in days"
url: "https://alphasignal.ai/news/biohub-releases-esmc-a-protein-world-model-trained-on-2-8b-sequences"
author: "AlphaSignal Newsroom"
author_url: "https://alphasignal.ai/editorial-team"
company: "AlphaSignal"
company_url: "https://alphasignal.ai/company/alphasignal"
published: "2026-06-11T02:09:02.000Z"
updated: "2026-06-09T10:54:16.067Z"
type: "Repo"
topics:
  - "Llms"
  - "Open Source"
subtopics:
  - "Vision Language"
  - "Small Models"
  - "Long Context"
upvotes: 3630
source_url: "https://github.com/Biohub/esm"
comments: 0
truncated: true
---

# Biohub Releases ESMC, a Protein World Model Trained on 2.8B Sequences

> Biohub open-sources ESMC, ESMFold2, and a 6.8B-protein Atlas — beating AlphaFold 3 on antibody-antigen prediction and designing lab-validated cancer binders in days

[Biohub](https://biohub.org/news/world-model-of-protein-biology/) has released what it calls a world model of protein biology: three open artifacts , ESMC, ESMFold2, and ESM Atlas , that together form a scientific engine for predicting protein structure, designing new binders, and navigating the protein universe at a scale not previously possible. The release comes from the team behind the ESM model family, which Biohub absorbed when it recruited EvolutionaryScale just seven months ago.

## Three pieces, one system

The release bundles three distinct but tightly coupled components:

* **ESMC** , a protein language model (PLM) trained on approximately 2.8 billion protein sequences drawn from across all of life, including organisms in extreme environments and the 20,000+ protein types in the human body. A PLM works like a text language model but over amino acid sequences: it learns to predict masked residues and, in doing so, internalizes the physical rules governing how proteins fold and function.

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## Sources

- [Biohub releases a world model of protein biology](https://biohub.org/news/world-model-of-protein-biology/)
- [GitHub - Biohub/esm](https://github.com/Biohub/esm)
- [ESMFold2 on Hugging Face](https://huggingface.co/biohub/ESMFold2)
- [BioByte 162: ESMC's AlphaFold3-Like Performance](https://decodingbio.substack.com/p/biobyte-162-the-hype-of-virtual-cells)
- [Biohub's ESM — newsletter.kiin.bio](https://newsletter.kiin.bio/p/biohubs-esm-georgia-techs-synfit)